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Dermatology
Journal Watch condenses summaries of key research across specialties from more than 250 medical journals into concise yet comprehensive articles, incorporating clinical commentary from prominent physician-editors in the field.
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Featured Article
SUMMARY AND COMMENT
A Proposed Mechanism Behind SCC Formation in Vemurafenib RecipientsFree
- January 20, 2012
- Kenneth Y. Tsai, MD, PhD
The presence of RAS mutations suggests that preexisting keratinocytes bearing these mutations are unmasked by vemurafenib
- Reviewing:
- Su F et al. N Engl J Med 2012 Jan 19; 366:207
Recent Dermatology Articles
SUMMARY AND COMMENT
Stem Cells on the Clock: Circadian Rhythm Proteins Regulate Epidermal Stem Cells
- January 20, 2012
- Kenneth Y. Tsai, MD, PhD
Investigators found an association between expression of genes associated with stem cell function and expression of circadian rhythm genes.
- Reviewing:
- Janich P et al. Nature 2011 Dec 8; 480:209
SUMMARY AND COMMENT
FCGR2A as a Susceptibility Locus for Kawasaki Disease
- January 20, 2012
- Kenneth Y. Tsai, MD, PhD
A genome-wide association study points to a susceptibility locus linking Kawasaki disease to an immune mediator.
- Reviewing:
- Khor CC et al. Nat Genet 2011 Nov 13; 43:1241
SUMMARY AND COMMENT
Vitamin D and UVB Radiation: How Much Is Necessary?Free
- January 13, 2012
- Craig A. Elmets, MD
For individuals unable to benefit from supplements, ultraviolet B exposure every 2 weeks may be an alternative.
- Reviewing:
- Bogh MKB et al. Br J Dermatol 2011 Oct 20
SUMMARY AND COMMENT
Etanercept for Treatment of Dermatomyositis
- January 13, 2012
- Jeffrey P. Callen, MD
Etanercept allowed patients to discontinue or decrease prednisone in a small study.
- Reviewing:
- Amato AA et al. for the Muscle Study Group. Ann Neurol 2011 Sep; 70:427
SUMMARY AND COMMENT
Childhood Dermatomyositis and Increased Cardiovascular Disease Risk Factors in Adulthood
- January 13, 2012
- Jeffrey P. Callen, MD
Adults with a history of JDM had more evidence of disease than matched controls.
- Reviewing:
- Eimer MJ et al. J Pediatr 2011 Nov; 159:795
SUMMARY AND COMMENT
Thalidomide Treatment of Cutaneous Lupus Erythematosus
- January 13, 2012
- Jeffrey P. Callen, MD
Thalidomide was effective in 98% of patients with refractory CLE.
- Reviewing:
- Cortés-Hernández J et al. Br J Dermatol 2011 Oct 16
SUMMARY AND COMMENT
Combination Corticosteroid plus IVIG for Treatment-Resistant Kawasaki Disease
- January 13, 2012
- Mary Wu Chang, MD
Adding methylprednisolone to IV immunoglobulin eliminated fever and led to greater coronary artery dimension in children predicted to be IVIG-resistant.
- Reviewing:
- Ogata S et al. Pediatrics 2011 Dec 5
SUMMARY AND COMMENT
More Evidence That Combined Tacrolimus and Narrowband UVB Are Useful for VitiligoFree
- January 6, 2012
- Craig A. Elmets, MD
Combined treatment was better than ultraviolet treatment alone, and the effects were tacrolimus dose-dependent.
- Reviewing:
- Nordal EJ et al. J Eur Acad Dermatol Venereol 2011 Dec; 25:1440
SUMMARY AND COMMENT
Granulomatous Processes and Clonality: PCR Evaluation of T-Cell Rearrangement for Diagnosis
- January 6, 2012
- Angelica Selim, MD
Analysis of T-cell clonality is useful for differentiating sarcoidosis and primary granuloma annulare from granulomatous CTCLs.
- Reviewing:
- Pfaltz K et al. Am J Dermatopathol 2011 Oct; 33:659
LETTER TO READERS
Dermatology Top Stories of 2011Free
- December 30, 2011
- Hensin Tsao, MD, PhD
A perspective on the most important research in the field from the past year
Journal Watch Dermatology summarizes important medical journal articles about a wide variety of dermatologic subjects including atopic dermatitis, eczema, hemangioma, melanoma, phototherapy, psoriasis and scleroderma.
