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Search for Melanoma in Dermatology
Physician-authored summaries on the latest research on melanoma, editorials on melanoma, and perspectives on melanoma - drawn from the top medical journals.
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You searched for: melanoma in Dermatology
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Melanoma Surveillance in the Digital Age
- May 11, 2012
- Hensin Tsao, MD, PhD
- Dermatology
The most frequent dermatoscopic features associated with melanoma were focal changes in pigmentation or structure.- Reviewing:
- Salerni G et al., J Am Acad Dermatol 2012 Apr 19;:
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Awakening the Giant — p53 Reactivation Potentiates Melanoma Therapy Free
- March 23, 2012
- Kenneth Y. Tsai, MD, PhD
- Dermatology
Restoring TP53 tumor-suppressive signaling via HDM2 inhibition to suppress melanoma growth- Reviewing:
- Ji Z et al., J Invest Dermatol 2012 Feb; 132:356. Verhaegen M et al., Oncogene 2012 Feb 16; 31:828.
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Fine MAPping in Melanoma
- March 16, 2012
- Hensin Tsao, MD, PhD
- Dermatology
Researchers identify recurrent somatic mutations in genes in the MAP kinase pathway.- Reviewing:
- Stark MS et al., Nat Genet 2012 Feb; 44:165. Nikolaev SI et al., Nat Genet 2012 Feb; 44:133.
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A Rare Variant Confers Risk for Melanoma and Renal Carcinoma
- December 9, 2011
- Kenneth Y. Tsai, MD, PhD
- Dermatology
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma and renal cell cancer.- Reviewing:
- Yokoyama S et al., Nature 2011 Nov 13;: Bertolotto C et al., Nature 2011 Oct 19;:
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Less Is More — Number Needed to Excise Decreased as Accurate Melanoma Diagnosis Increased
- October 21, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Accuracy improved during a 10-year period in specialized clinics in 13 countries.- Reviewing:
- Argenziano G et al., J Am Acad Dermatol 2011 Oct 6;:
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Minimal Nodal Disease in SLN Melanoma Indicates Better Survival Free
- July 15, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Smaller tumor burden and location in the subcapsular area were associated with better outcomes.- Reviewing:
- van der Ploeg APT et al., J Clin Oncol 2011 Jun 1; 29:2206.
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Mutation to Medicine: Improved Survival with Vemurafenib in Melanoma Free
- June 6, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Patients with unresectable melanoma and the BRAF V600E mutation saw rapid response and improved rates of overall and progression-free survival.- Reviewing:
- Chapman PB et al., N Engl J Med 2011 Jun 5;:
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Something New, Something Old: Adding Vaccine to Interleukin-2 for Advanced Melanoma Improves Response Free
- June 1, 2011
- Hensin Tsao, MD, PhD
- Dermatology
A gp-100 peptide vaccine added clinically modest but statistically significant survival effects in a small trial.- Reviewing:
- Schwartzentruber DJ et al., N Engl J Med 2011 Jun 2; 364:2119.
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New Technologies Reveal New Melanoma Genes Free
- May 13, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Whole-exome sequencing brings to light a novel oncogene, a tumor-suppressor gene, and new melanoma pathways.- Reviewing:
- Wei X et al., Nat Genet 2011 Apr 15;:
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Dusting for Fingerprints: Noninvasive Genomic Melanoma Detection Free
- April 29, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Tape stripping of the stratum corneum produced highly sensitive and specific melanoma identification.- Reviewing:
- Wachsman W et al., Br J Dermatol 2011 Apr; 164:797.
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Aspirin and NSAIDs Are Potential Chemopreventive Agents for Melanoma
- April 22, 2011
- Craig A. Elmets, MD
- Dermatology
Long-term use of nonsteroidal anti-inflammatory drugs was associated with a decreased risk.- Reviewing:
- Curiel-Lewandrowski C et al., J Invest Dermatol 2011 Mar 10;:
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Neural Crest Suppression and Melanoma
- April 8, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Drug screening joins gene discovery in the zebrafish tank, as researchers seek drugs that could prevent melanoma development.- Reviewing:
- White RM et al., Nature 2011 Mar 24; 471:518.
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Histones and Melanoma
- February 11, 2011
- Hensin Tsao, MD, PhD
- Dermatology
A histone variant suppresses melanoma progression through regulation of CDK8.- Reviewing:
- Kapoor A et al., Nature 2010 Dec 23/30; 468:1105.
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Does Ulceration Predict Response of Melanoma to Interferon?
- October 22, 2010
- Murad Alam, MD, MSCI
- Dermatology
Disease-free survival was better in patients with ulcerated melanoma.- Reviewing:
- McMasters KM et al., Ann Surg 2010 Sep; 252:460.
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Utility or Futility — Chest X-Rays for Melanoma Surveillance
- October 22, 2010
- Hensin Tsao, MD, PhD
- Dermatology
Routine chest radiography conveys no benefit.- Reviewing:
- Brown RE et al., Surgery 2010 Oct; 148:711.
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BRAF and Melanoma: Taking It Personally Free
- August 25, 2010
- Hensin Tsao, MD, PhD
- Dermatology
More than 80% of melanoma patients with an activating mutation in BRAF responded to treatment with PLX4032.- Reviewing:
- Flaherty KT et al., N Engl J Med 2010 Aug 26; 363:809. Smalley KSM and Sondak VK., N Engl J Med 2010 Aug 26; 363:876.
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Elastin: A Tool for Answering Another Important Question in Melanoma
- August 13, 2010
- Angelica Maria Selim, MD
- Dermatology
Elastin staining effectively showed differences between regressed melanoma and scars resulting from past procedures.- Reviewing:
- Kamino H et al., J Cutan Pathol 2010 Jul; 37:723.
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The Melanoma Stem Cell Controversy Continues Free
- July 30, 2010
- Hensin Tsao, MD, PhD
- Dermatology
Melanoma-initiating cells that express CD271 may be unaffected by antimelanoma immunotherapy.- Reviewing:
- Boiko AD et al., Nature 2010 Jul 1; 466:133.
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Parkinson Disease and Increased Melanoma Risk
- April 9, 2010
- Hensin Tsao, MD, PhD
- Dermatology
Evidence suggests that annual skin examination is reasonable for patients with Parkinson disease.- Reviewing:
- Bertoni JM et al., Arch Neurol 2010 Mar; 67:347.
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Melanoma —Plus Ça Change . . .
- March 19, 2010
- Hensin Tsao, MD, PhD
- Dermatology
Review of melanomas by a multidisciplinary tumor board resulted in revisions of diagnoses in many patients.- Reviewing:
- Santillan AA et al., J Clin Oncol 2010 Jan 20; 28:481.
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