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Search for Melanoma in Dermatology
Physician-authored summaries on the latest research on melanoma, editorials on melanoma, and perspectives on melanoma - drawn from the top medical journals.
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You searched for: melanoma in Dermatology
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Dermoscopic Evaluation of Nodular Melanoma Free
- April 19, 2013
- Hensin Tsao, MD, PhD
- Dermatology
Compared with nonnodular melanomas, a higher fraction of NMs are amelanotic.- Reviewing:
- Menzies SW et al., JAMA Dermatol 2013 Apr 3;:
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FTO, BMI, and Melanoma Risk
- March 22, 2013
- Hensin Tsao, MD, PhD
- Dermatology
A single nucleotide polymorphism significantly and independently associated with melanoma risk is identified in a gene otherwise associated with obesity.- Reviewing:
- Iles MM et al., Nat Genet 2013 Mar 3;:
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Aspirin May Prevent Melanoma in Postmenopausal Caucasian Women Free
- March 15, 2013
- Jeffrey P. Callen, MD
- Dermatology
In contrast to some earlier reports, in this large study, low-dose aspirin seemed to usefully reduce melanoma risk.- Reviewing:
- Gamba CA et al., Cancer 2013 Mar 11;:
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The Risk for Melanoma in Large, Congenital Melanocytic Nevi Free
- January 4, 2013
- Mary Wu Chang, MD
- Dermatology
After LCMN surgery, the risk for malignant transformation is reduced but not negligible, and scarring may affect cosmetic improvement.- Reviewing:
- Vourc'h-Jourdain M et al., J Am Acad Dermatol 2012 Nov 19;:
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Redheads Have More Sun (and Reactive Oxygen Species): A Surprising Link Between Melanin Production and Melanoma
- November 30, 2012
- Kenneth Y. Tsai, MD, PhD
- Dermatology
Although linkage of melanoma risk to ultraviolet radiation exposure is beyond doubt, ultraviolet-radiation–independent events are likely to have a considerable role.- Reviewing:
- Mitra D et al., Nature 2012 Nov 15; 491:449.
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Better Together: Combining BRAF and MEK Inhibitors Prolonged Progression-Free Survival in Metastatic Melanoma
- October 12, 2012
- Hensin Tsao, MD, PhD
- Dermatology
At their full monotherapy doses, the combination of dabrafenib and trametinib was effective and safe, despite some toxic effects.- Reviewing:
- Flaherty KT et al., N Engl J Med 2012 Sep 29;:
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More Is More: Two New Studies Identify Gene Mutations in Melanoma
- August 24, 2012
- Hensin Tsao, MD, PhD
- Dermatology
Sequencing identifies additional, though less prevalent, genes mutated in melanoma.- Reviewing:
- Hodis E et al., Cell 2012 Jul 20; 150:251. Krauthammer M et al., Nature Genet 2012 Jul 29;:
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Early Tanning Bed Use Raises Risk for Melanoma Free
- August 10, 2012
- Craig A. Elmets, MD
- Dermatology
More than 5% of melanomas are caused by tanning bed use.- Reviewing:
- Boniol M et al., BMJ 2012 Jul 24; 345:e4757.
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Inhibiting the Inhibitor: MDM4 as a Therapeutic Target in Cutaneous Melanoma
- August 3, 2012
- Kenneth Y. Tsai, MD, PhD
- Dermatology
Another strategy for restoring p53 function in melanoma emerges.- Reviewing:
- Gembarska A et al., Nat Med 2012 Jul 22;:
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Tumor-Infiltrating Lymphocytes Predict SLN Status and Prognosis in Melanoma Free
- June 29, 2012
- Hensin Tsao, MD, PhD
- Dermatology
Melanoma-specific survival rate increases with a higher TIL grade.- Reviewing:
- Azimi F et al., Oncol 2012 Jun 18;:
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Melanoma Surveillance in the Digital Age
- May 11, 2012
- Hensin Tsao, MD, PhD
- Dermatology
The most frequent dermatoscopic features associated with melanoma were focal changes in pigmentation or structure.- Reviewing:
- Salerni G et al., J Am Acad Dermatol 2012 Apr 19;:
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Awakening the Giant — p53 Reactivation Potentiates Melanoma Therapy Free
- March 23, 2012
- Kenneth Y. Tsai, MD, PhD
- Dermatology
Restoring TP53 tumor-suppressive signaling via HDM2 inhibition to suppress melanoma growth- Reviewing:
- Ji Z et al., J Invest Dermatol 2012 Feb; 132:356. Verhaegen M et al., Oncogene 2012 Feb 16; 31:828.
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Fine MAPping in Melanoma
- March 16, 2012
- Hensin Tsao, MD, PhD
- Dermatology
Researchers identify recurrent somatic mutations in genes in the MAP kinase pathway.- Reviewing:
- Stark MS et al., Nat Genet 2012 Feb; 44:165. Nikolaev SI et al., Nat Genet 2012 Feb; 44:133.
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A Rare Variant Confers Risk for Melanoma and Renal Carcinoma
- December 9, 2011
- Kenneth Y. Tsai, MD, PhD
- Dermatology
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma and renal cell cancer.- Reviewing:
- Yokoyama S et al., Nature 2011 Nov 13;: Bertolotto C et al., Nature 2011 Oct 19;:
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Less Is More — Number Needed to Excise Decreased as Accurate Melanoma Diagnosis Increased
- October 21, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Accuracy improved during a 10-year period in specialized clinics in 13 countries.- Reviewing:
- Argenziano G et al., J Am Acad Dermatol 2011 Oct 6;:
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Minimal Nodal Disease in SLN Melanoma Indicates Better Survival Free
- July 15, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Smaller tumor burden and location in the subcapsular area were associated with better outcomes.- Reviewing:
- van der Ploeg APT et al., J Clin Oncol 2011 Jun 1; 29:2206.
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Mutation to Medicine: Improved Survival with Vemurafenib in Melanoma Free
- June 6, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Patients with unresectable melanoma and the BRAF V600E mutation saw rapid response and improved rates of overall and progression-free survival.- Reviewing:
- Chapman PB et al., N Engl J Med 2011 Jun 5;:
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Something New, Something Old: Adding Vaccine to Interleukin-2 for Advanced Melanoma Improves Response Free
- June 1, 2011
- Hensin Tsao, MD, PhD
- Dermatology
A gp-100 peptide vaccine added clinically modest but statistically significant survival effects in a small trial.- Reviewing:
- Schwartzentruber DJ et al., N Engl J Med 2011 Jun 2; 364:2119.
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New Technologies Reveal New Melanoma Genes Free
- May 13, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Whole-exome sequencing brings to light a novel oncogene, a tumor-suppressor gene, and new melanoma pathways.- Reviewing:
- Wei X et al., Nat Genet 2011 Apr 15;:
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Dusting for Fingerprints: Noninvasive Genomic Melanoma Detection Free
- April 29, 2011
- Hensin Tsao, MD, PhD
- Dermatology
Tape stripping of the stratum corneum produced highly sensitive and specific melanoma identification.- Reviewing:
- Wachsman W et al., Br J Dermatol 2011 Apr; 164:797.
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