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Physician-authored summaries on the latest research on psoriasis, editorials on psoriasis, and perspectives on psoriasis - drawn from the top medical journals.
You searched for: psoriasis Items 1 to 20 of 205 results
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Therapy for Pediatric Psoriasis Gets a Shot in the ArmFree!
- January 16, 2008
- Craig A. Elmets, MD
Although several biologic agents have received FDA approval for treating psoriasis in adults, none have been evaluated for pediatric patients. To evaluate the safety and . . .- Covering:
- Paller AS et al., N Engl J Med 2008 Jan 17; 358:241.
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Psoriasis Is Related to Weight Gain in Women
- August 17, 2007
- Jeffrey P. Callen, MD
Another piece of the psoriasis and obesity puzzle falls into place.- Covering:
- Setty AR et al., Arch Intern Med 2007 Aug 13; 167:1670-5.
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A T-Cell/Collagen IV Connection in Psoriasis
- August 10, 2007
- Hensin Tsao, MD, PhD
Collagen IV and its receptor, α1β1 integrin, seem to have a substantial role in the pathogenesis of psoriasis.- Covering:
- Conrad C et al., Nat Med 2007 Jul; 13:836-42.
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Beyond Skin and Joints: Psoriasis and the Metabolic Syndrome
- July 13, 2007
- Jeffrey P. Callen, MD
Researchers identified the metabolic syndrome in 30% of psoriasis patients seen at tertiary skin centers.- Covering:
- Gisondi P et al., Br J Dermatol 2007 Jul; 157:68-73.
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Psoriasis Fights BackFree!
- March 23, 2007
- Mark V. Dahl, MD
TNF-α inhibition may activate psoriasis or pustular dermatitis in some recipients.- Covering:
- de Gannes GC et al., Arch Dermatol 2007 Feb; 143:223-31.
- Ubriani R and Van Voorhees AS., Arch Dermatol 2007 Feb; 143:270-2.
- Fiorentino DF., Arch Dermatol 2007 Feb; 143:233-6.
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Biologics for Psoriasis: The Second GenerationFree!
- February 9, 2007
- Craig A. Elmets, MD
A promising new treatment for psoriasis had high efficacy, few adverse effects in phase II trial.- Covering:
- Krueger GG et al., N Engl J Med 2007 Feb 8; 356:580-92.
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Health Implications of Psoriasis: More Than Just Skin DeepFree!
- October 27, 2006
- Craig A. Elmets, MD
The inflammatory process might be involved in the association between psoriasis and myocardial infarction.- Covering:
- Gelfand JM et al., JAMA 2006 Oct 11; 296:1735-41.
- Gelfand JM et al., J Invest Dermatol 2006 Oct; 126:2194-201.
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Etanercept Alleviates Fatigue and Depression Along with Psoriasis
- February 28, 2006
- Jeffrey P. Callen, MD
When I first began using etanercept for psoriasis, I noted that many patients who returned for a first visit after initiating therapy reported how well . . .- Covering:
- Tyring S et al., Lancet 2006 Jan 7; 367:29-35.
- Bos JD and de Korte J., Lancet 2006 Jan 7; 367:6-7.
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Excimer Laser vs. Pulsed-Dye Laser for Psoriasis
- December 20, 2005
- George J. Hruza, MD
They target different aspects of the psoriasis pathway, so the PDL may be useful when the excimer laser is not.- Covering:
- Taibjee SM et al., Br J Dermatol 2005 Nov; 153:960-6.
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Induced Psoriasis in Mice Suggests a Role for Jun
- October 25, 2005
- Hensin Tsao, MD, PhD
Knocking out expression of the JunB gene in mouse epidermal cells led to a psoriasis-like condition in the skin and joints.- Covering:
- Zenz R et al., Nature 2005 Sep 15; 437:369-75.
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Additional Evidence for Innate Immune System Involvement in Psoriasis PathogenesisFree!
- October 19, 2007
- Craig A. Elmets, MD
The antimicrobial peptide LL37 converts inert self-DNA into a potent trigger of interferon production in psoriasis.- Covering:
- Lande R et al., Nature 2007 Oct 4; 449:564.
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Ustekinumab for Chronic Plaque Psoriasis
- May 30, 2008
- Jeffrey P. Callen, MD
This human monoclonal antibody significantly improved PASI scores, but some questions about its use remain.- Covering:
- Leonardi CL et al., Lancet 2008 May 17; 371:1665.
- Papp KA et al., Lancet 2008 May 17; 371:1675.
- Bartlett BL and Tyring SK., Lancet 2008 May 17; 371:1639.
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A Few More T Cells and Cytokines to Investigate in Psoriasis
- May 16, 2008
- Craig A. Elmets, MD
Th17 cells, known to be linked to autoimmune disorders, were found at elevated levels in psoriatic plaques.- Covering:
- Lowes MA et al., J Invest Dermatol 2008 May; 128:1207.
- Blauvelt A., J Invest Dermatol 2008 May; 128:1064.
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Grim News on Adverse Health Effects of Psoriasis
- January 25, 2008
- Craig A. Elmets, MD
Patients with severe disease have reduced life expectancy, but we don’t know why.- Covering:
- Gelfand JM et al., Arch Dermatol 2007 Dec; 143:1493.
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Are Liver Biopsies Necessary in Psoriasis Patients Treated with Methotrexate?Free!
- June 15, 2007
- Jeffrey P. Callen, MD
Patients with certain risk factors had increased rates of fibrosis.- Covering:
- Rosenberg P et al., J Hepatol 2007 Jun; 46:1111-8.
- Aithal GP., J Hepatol 2007 Jun; 46:995-8.
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What Is Severe Psoriasis?Free!
- March 16, 2007
- Mark V. Dahl, MD
Impact on a patient’s quality of life is more important than skin area in determining disease severity.- Covering:
- Pariser DM et al., Arch Dermatol 2007 Feb; 143:239-42.
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Etanercept for Pediatric Psoriasis
- April 25, 2006
- Mary Wu Chang, MD
Promising results were seen in two recent case series.- Covering:
- Kress DW., J Am Acad Dermatol 2006 Mar; 54:S126-8.
- Hawrot AC et al., Pediatr Dermatol 2006 Jan/Feb; 23:67-71.
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Can We Save Our Patients with Psoriasis from Liver Biopsy?
- May 24, 2005
- Jeffrey P. Callen, MD
The guidelines published by the American Academy of Dermatology (see J Am Acad Dermatol 1998; 38:478) suggest that intermittent liver biopsy be performed in . . .- Covering:
- Chalmers RJG et al., Br J Dermatol 2005 Mar; 152:444-50.
- Maurice PDL et al., Br J Dermatol 2005 Mar; 152:451-8.
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The N-of-1 Trial: Implications for Biologic Therapies in Psoriasis
- June 6, 2008
- Jeffrey P. Callen, MD
A new strategy that is designed to improve on the “stepped care” approach compares therapies in individual patients.- Covering:
- Kravitz RL et al., Arch Intern Med 2008 May 26; 168:1030.
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Now, Another Reason to Advise Patients Not to Smoke
- December 7, 2007
- Jeffrey P. Callen, MD
Smokers had increased rates of psoriasis, and even secondary exposure conveyed some increase in risk.- Covering:
- Setty AR et al., Am J Med 2007 Nov; 120:953.
You searched for: psoriasis Items 1 to 20 of 205 results