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Search for Scleroderma in Dermatology
Physician-authored summaries on the latest research on scleroderma, editorials on scleroderma, and perspectives on scleroderma - drawn from the top medical journals.
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You searched for: scleroderma in Dermatology
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Or, narrow your search to one topic: systemic scleroderma scleroderma
Or, narrow your search to one topic: systemic scleroderma scleroderma
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Is Localized Scleroderma in Childhood a Systemic Disease?
- September 27, 2005
- Jeffrey P. Callen, MD
- Dermatology
Scleroderma is rare in children. It has been subclassified as localized scleroderma and systemic scleroderma. Localized scleroderma has been further divided into plaque morphea, generalized . . .- Reviewing:
- Zulian F et al., Arthritis Rheum 2005 Sep; 52:2873-81.
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Methotrexate with Pulsed Methylprednisolone Is Effective for Localized Scleroderma
- August 9, 2005
- Jeffrey P. Callen, MD
- Dermatology
Hardening and thickening of the dermis, the subcutis, and, sometimes, the underlying soft tissue and bone characterize localized scleroderma (LS). This condition has been classified . . .- Reviewing:
- Kreuter A et al., Arch Dermatol 2005 Jul; 141:847-52.
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Hearing What There Is to Say About Scleroderma and the Ear
- June 20, 2008
- Craig A. Elmets, MD
- Dermatology
Disordered hearing and balance can occur in patients with scleroderma.- Reviewing:
- Amor-Dorado JC et al., Medicine (Baltimore) 2008 May; 87:131.
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Imiquimod Might Be Effective for Localized Scleroderma
- December 20, 2005
- Jeffrey P. Callen, MD
- Dermatology
No uniformly effective therapy exists for localized scleroderma (morphea). Few placebo-controlled randomized trials have tested treatments for this condition, and the response to therapy is . . .- Reviewing:
- Dytoc M et al., Br J Dermatol 2005 Oct; 153:815-20.
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Methotrexate, With or Without Corticosteroids, Might Benefit Sclerosing Skin Disease
- March 20, 2009
- Jeffrey P. Callen, MD
- Dermatology
A couple of methotrexate regimens appeared beneficial, but study design throws the conclusions into question.- Reviewing:
- Kroft EBM et al., Br J Dermatol 2009 Feb 4;:
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Statins Might Benefit Digital Ulcerations and Raynaud Phenomenon
- October 17, 2008
- Jeffrey P. Callen, MD
- Dermatology
These relatively inexpensive agents hold promise for resolving digital ulcers in sclerosis-related Raynaud phenomenon.- Reviewing:
- Abou-Raya A et al., J Rheumatol 2008 Sep; 35:1801.
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A SNP in Systemic Sclerosis
- November 2, 2007
- Hensin Tsao, MD, PhD
- Dermatology
A polymorphism in the gene that expresses connective-tissue growth factor is involved in the risk for scleroderma.- Reviewing:
- Fonseca C et al., N Engl J Med 2007 Sep 20; 357:1210.
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Slash of the Sabre
- March 16, 2007
- Mary Wu Chang, MD
- Dermatology
En coup de sabre and Parry-Romberg syndrome are related forms of morphea/scleroderma.- Reviewing:
- Tollefson MM and Witman PM., J Am Acad Dermatol 2007 Feb; 56:257-63.
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Bosentan -- A New Oral Therapy for Severe Raynaud Phenomenon
- January 18, 2005
- Jeffrey P. Callen, MD
- Dermatology
An endothelin antagonist that blocks vasoconstriction looks promising.- Reviewing:
- Korn JH et al., Arthritis Rheum 2004 Dec; 50:3985-93. Ramos-Casals M et al., Rheumatology (Oxford) 2004 Nov; 43:1454-6.
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Restricted Cyclophosphamide Effective for Scleroderma Lung Disease, but at a Cost
- July 21, 2006
- Jeffrey P. Callen, MD
- Dermatology
Questions remain about associated risks as time goes by.- Reviewing:
- Tashkin DP et al., N Engl J Med 2006 Jun 22; 354:2655-66. Martinez FJ and McCune WJ., N Engl J Med 2006 Jun 22; 354:2707-9.
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Phototherapy for Localized Scleroderma
- March 28, 2006
- Jeffrey P. Callen, MD
- Dermatology
Good news from this first prospective trial of narrowband UVB for LS- Reviewing:
- Kreuter A et al., J Am Acad Dermatol 2006 Mar; 54:440-7.
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Localized Scleroderma in Children Is Effectively Managed with Methotrexate
- March 28, 2006
- Jeffrey P. Callen, MD
- Dermatology
Results of this small trial were promising.- Reviewing:
- Fitch PG et al., J Rheumatol 2006 Mar; 33:609-14.
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More Evidence for Autoimmune Disease in Localized Scleroderma
- January 18, 2005
- Jeffrey P. Callen, MD
- Dermatology
A variety of autoantibodies have been reported in patients with localized scleroderma (LSc). Thus far, the antibodies have neither been specific to these disorders nor . . .- Reviewing:
- Sato S et al., Br J Dermatol 2004 Dec; 151:1182-8.
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Localized Scleroderma Treated with Topical PUVA Cream
- January 12, 2001
- J Ferguson
- Dermatology
Although not usually as incapacitating as systemic sclerosis, localized scleroderma (LS) can significantly restrict a patient's mobility and quality of life. Current treatment options are . . .- Reviewing:
- Grundmann-Kollmann M et al., J Am Acad Dermatol 2000 Oct; 43:
675 678 .
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Methotrexate and Pulsed Methylprednisolone Are Effective for Localized Scleroderma in Children
- October 24, 2000
- JP Callen
- Dermatology
Localized scleroderma is more prevalent in children and can result in permanent contracture or deformity of underlying tissues. Recent reports have suggested several therapies for . . .- Reviewing:
- Uziel Y et al., J Pediatr 2000 Jan; 136:
91 95 .
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Cyclophosphamide May Provide Benefit in Scleroderma
- July 26, 2000
- R Saitz
- Dermatology
No treatment has been found to modify the outcome of scleroderma that involves the lung. These researchers report the results of a retrospective cohort study . . .- Reviewing:
- White B et al., Ann Intern Med 2000 Jun 20; 132:
947 954 .
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Oral Calcitriol for Linear Scleroderma
- April 1, 1999
- EC Siegfried
- Dermatology
Linear scleroderma carries a risk of significant adverse sequelae in children, including contractures and limb shortening, but safe and effective therapy has not been defined. . . .- Reviewing:
- Elst EF et al., Pediatr Dermatol 1999; 16:
53 58 . Kollias N., Arch Dermatol 1999; 135:209 210 .
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Histology Discriminates Localized from Systemic Scleroderma
- July 1, 1998
- BR Smoller
- Dermatology
Traditionally, it hasn't been thought possible to discriminate between localized scleroderma (morphea) and systemic disease on the basis of a skin biopsy. To test this . . .- Reviewing:
- Torres JE and Sanchez JL., Am J Dermatopathol 1998; 20:
242 245 .
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UVA1 Phototherapy for Localized Scleroderma
- April 1, 1998
- JS Dover
- Dermatology
A group of investigators in Germany previously reported the effectiveness of both bath PUVA and UVA1 phototherapy in the treatment of localized scleroderma (See . . .- Reviewing:
- Kerscher M et al., J Am Acad Dermatol 1998; 38:
21 26 .
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B. burgdorferi Plays No Role in Morphea, Scleroderma, or LS and A in North America
- December 1, 1995
- BR Smoller
- Dermatology
Many European studies have found a link between Borrelia burgdorferi infection and morphea, scleroderma, and lichen sclerosus et atrophicus (LS and A). In contrast, many . . .- Reviewing:
- Dillon WI et al., J Am Acad Dermatol 1995; 33:
617 620 .
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