Dermatology: Archives

SUMMARY AND COMMENT

"IL-22 T Cells" and Atopic DermatitisFree

• July 10, 2009
• Mark V. Dahl, MD

Increased numbers of IL-22–producing cells and increased expression differentiated AD from psoriasis and point the way for new therapies.

• Reviewing:
• Nograles KE et al., J Allergy Clin Immunol 2009 Jun; 123:e2

SUMMARY AND COMMENT

KIT’ing Around

• July 10, 2009
• Hensin Tsao, MD, PhD

Mutation of the KIT ligand increased melanin synthesis in a hereditary hyperpigmentation syndrome.

• Reviewing:
• Wang Z-Q et al., Am J Hum Genet 2009 May 15; 84:672

FEATURE

Looking Far Afield . . .

• July 10, 2009
• Lowell A. Goldsmith, MD, MPH

Researchers model an ingenious strategy for vector eradication in dengue fever.

• Reviewing:
• Devine GJ et al., Proc Natl Acad Sci U S A 2009 Jun 26

SUMMARY AND COMMENT

PPAR for the Melanoma Course

• July 2, 2009
• Mark V. Dahl, MD

Glitazones represent a new direction for developing molecularly targeted anticancer agents.

• Reviewing:
• Botton T et al., J Invest Dermatol 2009 May; 129:1208 Schadendorf D., J Invest Dermatol 2009 May; 129:1061

SUMMARY AND COMMENT

Pemphigoid Gestationis and Fetal Outcomes

• July 2, 2009
• Craig A. Elmets, MD

Infants of mothers with pemphigoid disease during pregnancy were more likely to be born prematurely or at low birth weight, but the adverse outcomes were not severe.

• Reviewing:
• Chi C-C et al., Br J Dermatol 2009 Jun; 160:1222

SUMMARY AND COMMENT

Ingenol Mebutate for Actinic KeratosesFree

• June 26, 2009
• George J. Hruza, MD

A short course of this plant-based agent significantly improved AK clearance.

• Reviewing:
• Anderson L et al., J Am Acad Dermatol 2009 Jun; 60:934

SUMMARY AND COMMENT

Rituximab of Little Help for Patients with Relapsing Polychondritis

• June 26, 2009
• Jeffrey P. Callen, MD

In a small, retrospective study, rituximab treatment did not produce meaningful improvement.

• Reviewing:
• Leroux G et al., Arthritis Rheum 2009 May 15; 61:577

SUMMARY AND COMMENT

Predicting When to Discontinue Pemphigoid Treatment

• June 26, 2009
• Mark V. Dahl, MD

ELISA or direct immunofluorescence testing should be performed before discontinuing suppressive therapy in patients with BP.

• Reviewing:
• Bernard P et al., Arch Dermatol 2009 May; 145:537

SUMMARY AND COMMENT

Newly Uncovered Aspects of Drug-Induced Hypersensitivity Syndrome

• June 12, 2009
• Jeffrey P. Callen, MD

In this prospective study, most eruptions occurred in the fall and winter, and many patients had cardiac involvement.

• Reviewing:
• Ben m’rad M et al., Medicine (Baltimore) 2009 May; 88:131

SUMMARY AND COMMENT

Home Phototherapy: An Overlooked Option for PsoriasisFree

• June 12, 2009
• Craig A. Elmets, MD

Patients were happy with home units for psoriasis phototherapy.

• Reviewing:
• Koek MBG et al., BMJ 2009 May 7; 338:b1542 Anstey A., BMJ 2009 May 7; 338:b607