Oncogenic Lesions in Lentigines
SUMMARY AND COMMENT
Researchers establish a genetic link between keratoses and lentigines, but not all mutations lead to cancer.
Reviewing:
Hafner C et al., Br J Dermatol 2009 Mar; 160:546
Infiltrate-Poor Pemphigoid
SUMMARY AND COMMENT
Inflammation is not always present when blisters develop in bullous pemphigoid.
Reviewing:
Iwata H et al., J Invest Dermatol 2009 Apr; 129:919
Sitaru C., J Invest Dermatol 2009 Apr; 129:822
The Bottom Line on Acral Melanoma
SUMMARY AND COMMENT
These tumors are not increasing in incidence as quickly as other melanomas, but they are associated with worse prognosis.
Reviewing:
Bradford PT et al., Arch Dermatol 2009 Apr; 145:427
Diabetes and Hypertension: Diseases Associated with Psoriasis
SUMMARY AND COMMENT
Two more systemic diseases are shown to be associated with psoriasis.
Reviewing:
Qureshi AA et al., Arch Dermatol 2009 Apr; 145:379
Etanercept Therapy for Toxic Epidermal Necrolysis?
SUMMARY AND COMMENT
TNF antagonist therapy is promising for TEN, but better evidence is needed.
Reviewing:
Gubinelli E et al., J Dermatol 2009 Mar; 36:150
The HORIZON Study: Bisphosphonates for Patients on Corticosteroids
SUMMARY AND COMMENT
Once-yearly infusion of a bisphosphonate may be more effective and more convenient than daily bisphosphonate for preventing and treating glucocorticortoid-induced osteroporosis.
Reviewing:
Reid DM et al., Lancet 2009 Apr 11; 373:1253
Gennari L and Bilezikian JP., Lancet 2009 Apr 11; 373:1225
Looking Far Afield . . .
FEATURE
A laboratory automation system uses artificial intelligence and robotics to perform complete cycles of scientific experimentation.
Reviewing:
King RD et al., Science 2009 Apr 3; 324:85
TGFβ3 for Improving Surgical Scars
SUMMARY AND COMMENT
This agent improved visual appearance and the orientation of collagen fibers in scars in the first year of healing.
Reviewing:
Ferguson MWJ et al., Lancet 2009 Apr 11; 373:1264
Scarring After Ablative Fractional CO2 Laser Treatment
SUMMARY AND COMMENT
Caution is necessary when treating the neck with this device.
Reviewing:
Fife DJ et al., Lasers Surg Med 2009 Mar; 41:179
Avram MM et al., Lasers Surg Med 2009 Mar; 41:185
Tailored Moisturizers
SUMMARY AND COMMENT
Complex moisturizer ingredients not only retain transepidermal water but may also be able to correct specific deficits in barrier function.
Reviewing:
Buraczewska I et al., Arch Dermatol Res 2009 Feb; 301:175